Structure of PDB 7f55 Chain R Binding Site BS02

Receptor Information
>7f55 Chain R (length=273) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAV
ADMLVSVSNGSETIVITLLNSTSFTVNIDNVIDSVICSSLLASICSLLSI
AVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAV
IICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTQGANMKGAITL
TILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSII
DPLIYALRSQELRKTFKEIICCY
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7f55 Chain R Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7f55 Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		E100 D122 D126
Binding residue
(residue number reindexed from 1)		E62 D79 D83
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004977 melanocortin receptor activity
GO:0004980 melanocyte-stimulating hormone receptor activity
GO:0005515 protein binding
GO:0017046 peptide hormone binding
GO:0031625 ubiquitin protein ligase binding
GO:0042562 hormone binding
GO:0042923 neuropeptide binding
Biological Process
GO:0002024 diet induced thermogenesis
GO:0006112 energy reserve metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007631 feeding behavior
GO:0019222 regulation of metabolic process
GO:0030073 insulin secretion
GO:0032868 response to insulin
GO:0045780 positive regulation of bone resorption
GO:0060259 regulation of feeding behavior
GO:1903925 response to bisphenol A
GO:1903998 regulation of eating behavior
GO:1990680 response to melanocyte-stimulating hormone
GO:2000252 negative regulation of feeding behavior
GO:2000821 regulation of grooming behavior
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7f55, PDBe:7f55, PDBj:7f55
PDBsum7f55
PubMed34433901
UniProtP32245|MC4R_HUMAN Melanocortin receptor 4 (Gene Name=MC4R)

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