Structure of PDB 7f4h Chain R Binding Site BS02

Receptor Information
>7f4h Chain R (length=267) Species: 562,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDL
LVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFL
GAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDH
VAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKLKGAVTLTI
LLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDP
LIYAFHSQELRRTLKEV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7f4h Chain R Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7f4h Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		E94 D117 D121
Binding residue
(residue number reindexed from 1)		E59 D82 D86
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004977 melanocortin receptor activity
GO:0004980 melanocyte-stimulating hormone receptor activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008528 G protein-coupled peptide receptor activity
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0031625 ubiquitin protein ligase binding
GO:0042562 hormone binding
GO:0046872 metal ion binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0009650 UV protection
GO:0019222 regulation of metabolic process
GO:0019233 sensory perception of pain
GO:0022900 electron transport chain
GO:0032720 negative regulation of tumor necrosis factor production
GO:0035556 intracellular signal transduction
GO:0042438 melanin biosynthetic process
GO:0043473 pigmentation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060259 regulation of feeding behavior
GO:0070914 UV-damage excision repair
GO:0141163 positive regulation of cAMP/PKA signal transduction
GO:2000253 positive regulation of feeding behavior
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7f4h, PDBe:7f4h, PDBj:7f4h
PDBsum7f4h
PubMed34453129
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
Q01726

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