Structure of PDB 6rui Chain R Binding Site BS02

Receptor Information

>6rui Chain R (length=330) Species: 4932 (Saccharomyces cerevisiae)

MFEVPITLTNRKFAQRRKLKYQYINYISRRFDRISKKSSDEERKFWKKYE
KPEKSFEIWRTVSSQNKQPINKQKMTYHNFKKIEKIPLRKMEIPLLHCTK
ENKLYFQSISRGLEPLKTSTSEVRNYRTRHIVTLTDLLHLNVSRHNWSLA
YKIFATLIRIPGVQIKSLWGIGVEILDNLSNSSSGLDFLQWMCQIYSSKS
RFVQNINYRSIVPPFQTGSRTHTAKFAITYLWSSLINCQKSMLIDKISEW
VLTPPFMEDAEVWFIYASCHLLKADTLSRQFVNRDIKINQVIKHIHYVRT
FLKICLDKGGFAVPSRLIENQLKSFESRLY

Ligand information

>6rui Chain U (length=46)

tggagtacaagtgtgaggaaaagtagttgggacgaaagcagttgaa

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6rui Molecular insight into RNA polymerase I promoter recognition and promoter melting.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): R11 R125 T181 K182 N207
• Binding residue (residue number reindexed from 1): R11 R43 T99 K100 N125

Gene Ontology

Molecular Function

• GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding
• GO:0001181 RNA polymerase I general transcription initiation factor activity
• GO:0005515 protein binding
• GO:0017025 TBP-class protein binding

Biological Process

• GO:0001188 RNA polymerase I preinitiation complex assembly
• GO:0006361 transcription initiation at RNA polymerase I promoter
• GO:0042790 nucleolar large rRNA transcription by RNA polymerase I

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0070860 RNA polymerase I core factor complex

External links

• PDB: RCSB:6rui, PDBe:6rui, PDBj:6rui
• PDBsum: 6rui
• PubMed: 31804486
• UniProt: Q04712|RRN11_YEAST RNA polymerase I-specific transcription initiation factor RRN11 (Gene Name=RRN11)