Structure of PDB 6r7n Chain R Binding Site BS02

Receptor Information
>6r7n Chain R (length=86) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSE
ECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6r7n Chain R Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6r7n Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Resolution6.5 Å
Binding residue
(original residue number in PDB)		I49 E66 E67 C68 V70
Binding residue
(residue number reindexed from 1)		I33 E50 E51 C52 V54
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
2.3.2.32: cullin-RING-type E3 NEDD8 transferase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:6r7n, PDBe:6r7n, PDBj:6r7n
PDBsum6r7n
PubMed31444342
UniProtP62877|RBX1_HUMAN E3 ubiquitin-protein ligase RBX1 (Gene Name=RBX1)

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