Structure of PDB 6j6h Chain R Binding Site BS02

Receptor Information
>6j6h Chain R (length=261) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTSWRDKSAKVQVKESELPSSIPAQTGLTFNIWYNKWSQGFAGNTRFVSP
FALQPQLHSGKTRGDNDGQLFFCLFFAKGMCCLGPKCEYLHHIPDEEDIG
KLALRTEVLDCFGREKFADYREDMGGIGSFRKKNKTLYVGGIDGALNSKH
LKPAQIESRIRFVFSRLGDIDRIRYVESKNCGFVKFKYQANAEFAKEAMS
NQTLLLPSDKEWDDRREGTGLLVKWANEDPDPAAQKRLQEELKLESLNMM
VHLINNNTNSA
Ligand information
>6j6h Chain E (length=103) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacag
agaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagau
uua
<<<<<<<<<<.....>>>>>>>>>>.........................
............<<<..<<<.....>>>...>>>................
...
Receptor-Ligand Complex Structure
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PDB6j6h Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		P19 Y34 K36 S38 F41 R46 F47 S49 C73 L74 F75 M80 C81 C82 Y89 F117 D119 R121 G126 I127 G128 K196 S200 N201 L222 V223
Binding residue
(residue number reindexed from 1)		P19 Y34 K36 S38 F41 R46 F47 S49 C73 L74 F75 M80 C81 C82 Y89 F117 D119 R121 G126 I127 G128 K196 S200 N201 L222 V223
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0017070 U6 snRNA binding
GO:0036002 pre-mRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000387 spliceosomal snRNP assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0033120 positive regulation of RNA splicing
GO:0045292 mRNA cis splicing, via spliceosome
GO:0045787 positive regulation of cell cycle
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0071006 U2-type catalytic step 1 spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6j6h, PDBe:6j6h, PDBj:6j6h
PDBsum6j6h
PubMed30879786
UniProtQ12046|CWC2_YEAST Pre-mRNA-splicing factor CWC2 (Gene Name=CWC2)

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