Structure of PDB 6id0 Chain R Binding Site BS02

Receptor Information
>6id0 Chain R (length=272) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RKGWIPRLLEDFGDGGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKI
KYDAIARQGQSKDKVIYSKYTDLVPKEVMNADDPDLQRPDEEAIKEITEK
TRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYTPSQQGVAFNSGAKQRV
IRMVEMQKDPMEPPRFKINKKIPRGPPSPPAPVMHSPSRKMTVKEQQEWK
IPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADR
KAREAVEMRAQVERKMAQKEKE
Ligand information
>6id0 Chain H (length=140) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuauc
auuaauaucguccucuaccgaggacaauauuaaggauuuuuggagcaggg
aggcaucgaccugguauugcaguaccuccaggaacggugc
..................................................
....<<<..<<<<<<....>>>>>>..>>>....................
..<<<<<<.<<<<<.............>>>>>..>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6id0 Structures of the human spliceosomes before and after release of the ligated exon.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		K246 I247 N256 K258 Y260
Binding residue
(residue number reindexed from 1)		K200 I201 N210 K212 Y214
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0005112 Notch binding
GO:0005515 protein binding
GO:0016922 nuclear receptor binding
GO:0019899 enzyme binding
GO:0042809 nuclear vitamin D receptor binding
GO:0042974 nuclear retinoic acid receptor binding
GO:0046332 SMAD binding
GO:0050681 nuclear androgen receptor binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000398 mRNA splicing, via spliceosome
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043923 positive regulation by host of viral transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048026 positive regulation of mRNA splicing, via spliceosome
GO:0048384 retinoic acid receptor signaling pathway
GO:0048385 regulation of retinoic acid receptor signaling pathway
GO:0050769 positive regulation of neurogenesis
GO:0070562 regulation of vitamin D receptor signaling pathway
GO:0070564 positive regulation of vitamin D receptor signaling pathway
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0008024 cyclin/CDK positive transcription elongation factor complex
GO:0016363 nuclear matrix
GO:0016604 nuclear body
GO:0016607 nuclear speck
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Cellular Component
External links
PDB RCSB:6id0, PDBe:6id0, PDBj:6id0
PDBsum6id0
PubMed30728453
UniProtQ13573|SNW1_HUMAN SNW domain-containing protein 1 (Gene Name=SNW1)

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