Structure of PDB 5cdo Chain R Binding Site BS02

Receptor Information
>5cdo Chain R (length=477) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMT
PDKSYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGN
FGSMDGDGAAAMRYTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSV
LPARFPNLLANGASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAEL
MEDIEGPDFPTAGLILGKSGIRRAYETGRGSIQMRSRAVIEERQRIVVTE
IPFQVNKARMIEKIAELVRDKKIDGITDLRDETSLRTGVRVVIDVRKDAN
ASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEHQKTVV
RRRTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQ
RFKLSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELETILADEE
VLLQLVRDELTEIRDRFGDDRRTEIQL
Ligand information
Receptor-Ligand Complex Structure
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PDB5cdo Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.
Resolution3.15 Å
Binding residue
(original residue number in PDB)		R33 H79 H81 G82 S85 R92 R272
Binding residue
(residue number reindexed from 1)		R24 H70 H72 G73 S76 R83 R259
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:5cdo, PDBe:5cdo, PDBj:5cdo
PDBsum5cdo
PubMed26640131
UniProtQ99XG5|GYRA_STAAN DNA gyrase subunit A (Gene Name=gyrA)

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