Structure of PDB 8otz Chain QM Binding Site BS02

Receptor Information

>8otz Chain QM (length=431) Species: 9913 (Bos taurus)

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDSFNTFFSETGA
GKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHY
TIGKEIVDLVLDRIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLS
VDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEA
IYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTN
LVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPR
HGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQ
PPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKLDLMYAKRAFVHWY
VGEGMEEGEFSEAREDLAALEKDYEEVGVDS

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8otz Chain QM Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8otz Structural specializations of the sperm tail.
• Resolution: 3.6 Å
• Binding residue (original residue number in PDB): D69 E71 T145
• Binding residue (residue number reindexed from 1): D61 E63 T137
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.5.-

Gene Ontology

Molecular Function

• GO:0005200 structural constituent of cytoskeleton
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000226 microtubule cytoskeleton organization
• GO:0000278 mitotic cell cycle
• GO:0007017 microtubule-based process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005874 microtubule

External links

• PDB: RCSB:8otz, PDBe:8otz, PDBj:8otz
• PDBsum: 8otz
• PubMed: 37327785
• UniProt: Q32KN8|TBA3_BOVIN Tubulin alpha-3 chain (Gene Name=TUBA3)