Structure of PDB 8efr Chain Q Binding Site BS02

Receptor Information
>8efr Chain Q (length=766) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATDRGSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELR
KLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVV
GDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVALFKDS
SREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRM
VLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAE
RSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMK
ALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRNL
SLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELF
EKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTM
NSGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHD
DIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAA
IYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNETKNE
LEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRH
FLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTL
RQQLTNTEVRRLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVRE
IQEKLDAFIEALHQEK
Ligand information
Ligand IDALF
InChIInChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4
InChIKeyUYOMQIYKOOHAMK-UHFFFAOYSA-J
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		F[Al-](F)(F)F
FormulaAl F4
NameTETRAFLUOROALUMINATE ION
ChEMBL
DrugBankDB04444
ZINC
PDB chain8efr Chain Q Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8efr OPA1 helical structures give perspective to mitochondrial dysfunction.
Resolution5.48 Å
Binding residue
(original residue number in PDB)		D296 Q297 K301 M321 T323
Binding residue
(residue number reindexed from 1)		D102 Q103 K107 M127 T129
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.5: dynamin GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:8efr, PDBe:8efr, PDBj:8efr
PDBsum8efr
PubMed37612506
UniProtO60313|OPA1_HUMAN Dynamin-like GTPase OPA1, mitochondrial (Gene Name=OPA1)

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