Structure of PDB 6z86 Chain Q Binding Site BS02

Receptor Information
>6z86 Chain Q (length=190) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSEEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKG
YQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLP
NKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALRPAGVGVVVEA
THMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLI
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6z86 Chain Q Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6z86 A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.
Resolution2.206 Å
Binding residue
(original residue number in PDB)		C141 H144 C212
Binding residue
(residue number reindexed from 1)		C83 H86 C154
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) C141 E142 H143 H144 Q182 H210 C212
Catalytic site (residue number reindexed from 1) C83 E84 H85 H86 Q124 H152 C154
Enzyme Commision number 3.5.4.16: GTP cyclohydrolase I.
Gene Ontology
Molecular Function
GO:0003934 GTP cyclohydrolase I activity
Biological Process
GO:0046654 tetrahydrofolate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6z86, PDBe:6z86, PDBj:6z86
PDBsum6z86
PubMed33229582
UniProtP30793|GCH1_HUMAN GTP cyclohydrolase 1 (Gene Name=GCH1)

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