Structure of PDB 6ezm Chain Q Binding Site BS02

Receptor Information
>6ezm Chain Q (length=212) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EQKALVKRITNETKIQIAISLKGGPLAIEHSIFPEKAEQATQSQVINVHT
GIGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTTEDCGIALGQAFKEA
LGAVRGVKRFGSGFAPLDEALSRAVVDLSNRPYAVVELGLQREKVGDLSC
EMIPHFLESFAEASRITLHVDCLRGKNDHHRSESAFKALAVAIREATSPN
GTNDVPSTKGVL
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6ezm Chain A Residue 404 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6ezm Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H90 E94 H162
Binding residue
(residue number reindexed from 1)		H83 E87 H155
Annotation score1
Enzymatic activity
Enzyme Commision number 4.2.1.19: imidazoleglycerol-phosphate dehydratase.
Gene Ontology
Molecular Function
GO:0004424 imidazoleglycerol-phosphate dehydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0000105 L-histidine biosynthetic process
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ezm, PDBe:6ezm, PDBj:6ezm
PDBsum6ezm
PubMed29434040
UniProtP06633|HIS7_YEAST Imidazoleglycerol-phosphate dehydratase (Gene Name=HIS3)

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