Structure of PDB 5umd Chain Q Binding Site BS02

Receptor Information
>5umd Chain Q (length=189) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRRPARCYRYCKNKPYPKSRYCRGVPDPKIRIYDMGRKKADVNEFSGVVH
LVSYEYEQISSEALEAARISANKYMITNCGKDNFHLRVRIHPFHVLRINK
AFGKPNGVVARVDIGQVLLSIRTKENFVSKACEALRRAKYKFPGRQKVFV
SNKWGFTPFSKDEYQQYKKKGRIISDGVSCKFIREKGPL
Ligand information
>5umd Chain B (length=118) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gacucguucauacuacaguggauacaccagaucccaucagaacucugaag
uuaagcacuguaaggcuuggcuaguacugaggugggagaccgcucgggaa
caccaggugaugagucag
<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..>
>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>...
..>>>>>>>>>>>>>>..
Receptor-Ligand Complex Structure
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PDB5umd Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		Y11 E56 Y57 R201 E202 K203 G204 P205 L206
Binding residue
(residue number reindexed from 1)		Y10 E55 Y56 R184 E185 K186 G187 P188 L189
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5umd, PDBe:5umd, PDBj:5umd
PDBsum5umd
PubMed28288098
UniProtQ8ILV2

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