Structure of PDB 2bcj Chain Q Binding Site BS02
Receptor Information
>2bcj Chain Q (length=317) Species:
10090,10116
[
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
RELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVYQNIFTAM
QAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWN
DPGIQECYDRRREYQLSDSTKYYLNDLDRVADPSYLPTQQDVLRVRVPTT
GIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQ
VLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSH
LVDYFPEYDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENI
RFVFAAVKDTILQLNLK
Ligand information
Ligand ID
ALF
InChI
InChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4
InChIKey
UYOMQIYKOOHAMK-UHFFFAOYSA-J
SMILES
Software
SMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0
F[Al-](F)(F)F
Formula
Al F4
Name
TETRAFLUOROALUMINATE ION
ChEMBL
DrugBank
DB04444
ZINC
PDB chain
2bcj Chain Q Residue 362 [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
2bcj
Snapshot of Activated G Proteins at the Membrane: The Gq-GRK2-G Complex
Resolution
3.061 Å
Binding residue
(original residue number in PDB)
G48 E49 K52 R183 P185 T186 G208 Q209
Binding residue
(residue number reindexed from 1)
G11 E12 K15 R146 P148 T149 G171 Q172
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
E49 T54 D205
Catalytic site (residue number reindexed from 1)
E12 T17 D168
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0001664
G protein-coupled receptor binding
GO:0003924
GTPase activity
GO:0003925
G protein activity
GO:0005515
protein binding
GO:0005525
GTP binding
GO:0016787
hydrolase activity
GO:0019001
guanyl nucleotide binding
GO:0030234
enzyme regulator activity
GO:0031683
G-protein beta/gamma-subunit complex binding
GO:0046872
metal ion binding
GO:0047391
alkylglycerophosphoethanolamine phosphodiesterase activity
Biological Process
GO:0001501
skeletal system development
GO:0001508
action potential
GO:0007165
signal transduction
GO:0007186
G protein-coupled receptor signaling pathway
GO:0007189
adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007200
phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007207
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
GO:0007215
glutamate receptor signaling pathway
GO:0007507
heart development
GO:0008217
regulation of blood pressure
GO:0009791
post-embryonic development
GO:0010543
regulation of platelet activation
GO:0016322
neuron remodeling
GO:0021884
forebrain neuron development
GO:0032024
positive regulation of insulin secretion
GO:0042711
maternal behavior
GO:0042733
embryonic digit morphogenesis
GO:0045634
regulation of melanocyte differentiation
GO:0048066
developmental pigmentation
GO:0060158
phospholipase C-activating dopamine receptor signaling pathway
GO:0086100
endothelin receptor signaling pathway
GO:0099105
ion channel modulating, G protein-coupled receptor signaling pathway
GO:1904888
cranial skeletal system development
GO:1990806
ligand-gated ion channel signaling pathway
Cellular Component
GO:0005634
nucleus
GO:0005794
Golgi apparatus
GO:0005834
heterotrimeric G-protein complex
GO:0005886
plasma membrane
GO:0016020
membrane
GO:0030425
dendrite
GO:0031965
nuclear membrane
GO:0044297
cell body
GO:0045202
synapse
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:2bcj
,
PDBe:2bcj
,
PDBj:2bcj
PDBsum
2bcj
PubMed
16339447
UniProt
P10824
|GNAI1_RAT Guanine nucleotide-binding protein G(i) subunit alpha-1 (Gene Name=Gnai1);
P21279
|GNAQ_MOUSE Guanine nucleotide-binding protein G(q) subunit alpha (Gene Name=Gnaq)
[
Back to BioLiP
]