Structure of PDB 8qbl Chain P Binding Site BS02

Receptor Information
>8qbl Chain P (length=309) Species: 469008 (Escherichia coli BL21(DE3)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAEYLNTFRLRNLGLPVMNNLHDMSKATRISVETLRLLIYTADFRYRIYT
VEKKGPEKRMRTIYQPSRELKALQGWVLRNILDKLSSSPFSIGFEKHQSI
LNNATPHIGANFILNIDLEDFFPSLTANKVFGVFHSLGYNRLISSVLTKI
CCYKNLLPQGAPSSPKLANLICSKLDYRIQGYAGSRGLIYTRYADDLTLS
AQSMKKVVKARDFLFSIIPSEGLVINSKKTCISGPRSQRKVTGLVISQEK
VGIGREKYKEIRAKIHHIFCGKSSEIEHVRGWLSFILSVDSKSHRRLITY
ISKLEKKYG
Ligand information
>8qbl Chain Q (length=85) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gtcagaaaaaacgggtttcctggttggctcggagagcatcaggcgatgct
ctccgttccaacaaggaaaacagacagtaactcag
Receptor-Ligand Complex Structure
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PDB8qbl Retron-Eco1 assembles NAD + -hydrolyzing filaments that provide immunity against bacteriophages.
Resolution2.66 Å
Binding residue
(original residue number in PDB)		E35 L39 Y42 F46 R47 R70 K73 A129 N130 K131 F133 V135 S138 S147 T150 K156 L172 I173 R180 G183 Y195 K211 T244 H280 G283 W284 F287
Binding residue
(residue number reindexed from 1)		E33 L37 Y40 F44 R45 R68 K71 A127 N128 K129 F131 V133 S136 S145 T148 K154 L170 I171 R178 G181 Y193 K209 T242 H278 G281 W282 F285
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006974 DNA damage response
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:8qbl, PDBe:8qbl, PDBj:8qbl
PDBsum8qbl
PubMed38788717
UniProtP23070|RT86_ECOLX Retron Ec86 reverse transcriptase (Gene Name=ret)

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