Structure of PDB 7xd9 Chain P Binding Site BS02

Receptor Information
>7xd9 Chain P (length=616) Species: 11060 (dengue virus type 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSA
SSMVNGVVRLLTKPWDIIPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEPK
EGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDEN
KWKSAREAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGK
AKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLGY
ILRDVSKKEGMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIF
KLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQL
IRQMEGEGVFKSIQHEEIAVKNWLVRVGRERLSRMAISGDDCVVKPLDDR
FASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRV
LVVPCRNQDELIGRARISQGAGWSLRETACLGKSYAQMWSLMYFHRRDLR
LAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSL
IGNEEYTDYMPSMKRF
Ligand information
Receptor-Ligand Complex Structure
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PDB7xd9 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases.
Resolution2.58 Å
Binding residue
(original residue number in PDB)		S405 S661 D664 C709 S710 R729 Y758 M761 T790 S791 R792
Binding residue
(residue number reindexed from 1)		S138 S388 D391 C436 S437 R456 Y485 M488 T517 S518 R519
Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7xd9, PDBe:7xd9, PDBj:7xd9
PDBsum7xd9
PubMed36577062
UniProtQ91H74

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