Structure of PDB 6usj Chain P Binding Site BS02

Receptor Information
>6usj Chain P (length=87) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENV
IRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
Ligand information
>6usj Chain T (length=159) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcgccaggcctgagaatccggtgccgaggccgctcaattggtcgtagac
agctctagcaccgcttaaacgcacgtacgcgctgtcccccgcgttttaac
cgccaaggggattactccctagtctccaggcacgtgtcagatatatacat
ccaggcctt
Receptor-Ligand Complex Structure
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PDB6usj Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1.
Resolution10.5 Å
Binding residue
(original residue number in PDB)		R17 H18 R19 T30 P32 R36 K44 K77
Binding residue
(residue number reindexed from 1)		R2 H3 R4 T15 P17 R21 K29 K62
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0032200 telomere organization
GO:0045653 negative regulation of megakaryocyte differentiation
GO:0061644 protein localization to CENP-A containing chromatin
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000786 nucleosome
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0043505 CENP-A containing nucleosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6usj, PDBe:6usj, PDBj:6usj
PDBsum6usj
PubMed33141820
UniProtP62805|H4_HUMAN Histone H4 (Gene Name=H4C1)

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