Structure of PDB 3hda Chain P Binding Site BS02

Receptor Information

>3hda Chain P (length=382) Species: 556 (Dickeya chrysanthemi)

NVSWNGTNVFGKSANLTFKFLQSVSSIPSGDTGFVKFNAEQIEQAKLSLQ
SWSDVANLTFTEVTGNKSANITFGNYTRDASGNLDYGTQAYAYYPGNYQG
AGSSWYNYNQSNIRNPGSEEYGRQTFTHEIGHALGLAHPGYNGHYGGAPM
IDDIAAIQRLYGANMTTRTGDSVYGFNSNTDRDFYTATDSSKALIFSVWD
AGGTDTFDFSGYSNNQRINLNEGSFSDVGGLKGNVSIAHGVTIENAIGGS
GNDILVGNSADNILQGGAGNDVLYGGAGADTLYGGAGRDTFVYGSGQDST
VAAYDWIADFQKGIDKIDLSAFRNEGQLSFVQDQFTGKGQEVMLQWDAAN
SITNLWLHEAGHSSVDFLVRIVGQAAQSDIIV

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 3hda Chain P Residue 480

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3hda Metzincin's canonical methionine is responsible for the structural integrity of the zinc-binding site
• Resolution: 2.131 Å
• Binding residue (original residue number in PDB): R265 G267 S269 D297 G299 D302
• Binding residue (residue number reindexed from 1): R168 G170 S172 D200 G202 D205
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.24.40: serralysin.

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0005509 calcium ion binding
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0031012 extracellular matrix

External links

• PDB: RCSB:3hda, PDBe:3hda, PDBj:3hda
• PDBsum: 3hda
• PubMed: 19558324
• UniProt: P16317|PRTC_DICCH Serralysin C (Gene Name=prtC)