Structure of PDB 2eij Chain P Binding Site BS02

Receptor Information

>2eij Chain P (length=259) Species: 9913 (Bos taurus)

HQTHAYHMVNPSPWPLTGALSALLMTSGLTMWFHFNSMTLLMIGLTTNML
TMYQWWRDVIRESTFQGHHTPAVQKGLRYGMILFIISEVLFFTGFFWAFY
HSSLAPTPELGGCWPPTGIHPLNPLEVPLLNTSVLLASGVSITWAHHSLM
EGDRKHMLQALFITITLGVYFTLLQASEYYEAPFTISDGVYGSTFFVATG
FHGLHVIIGSTFLIVCFFRQLKFHFTSNHHFGFEAAAWYWHFVDVVWLFL
YVSIYWWGS

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 2eij Chain P Residue 1262

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2eij A histidine residue acting as a controlling site for dioxygen reduction and proton pumping by cytochrome c oxidase
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): H148 H232 E236
• Binding residue (residue number reindexed from 1): H146 H230 E234
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 7.1.1.9: cytochrome-c oxidase.

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0009055 electron transfer activity

Biological Process

• GO:0006123 mitochondrial electron transport, cytochrome c to oxygen
• GO:0008535 respiratory chain complex IV assembly
• GO:0019646 aerobic electron transport chain
• GO:0022904 respiratory electron transport chain
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0016020 membrane
• GO:0045277 respiratory chain complex IV

External links

• PDB: RCSB:2eij, PDBe:2eij, PDBj:2eij
• PDBsum: 2eij
• PubMed: 17470809
• UniProt: P00415|COX3_BOVIN Cytochrome c oxidase subunit 3 (Gene Name=MT-CO3)