Structure of PDB 8sf7 Chain OI Binding Site BS02

Receptor Information

>8sf7 Chain OI (length=433) Species: 5911 (Tetrahymena thermophila)

MREVISIHVGQGGIQVGNACWELFCLEHGIQPDGQMPSGDDAFNTFFSET
GAGKHVPRAVFLDLEPTVIDEVRTGTYRQLFHPEQLISGKEDAANNFARG
HYTIGKEIVDLCLDRIRKLADNCTGLQGFLVFNSVGGGTGSGLGSLLLER
LSVDYGKKSKLGFTIYPSPQVSTAVVEPYNSILSTHSLLEHTDVAVMLDN
EAIYDICRRNLDIERPTYTNLNRLIAQVISSLTASLRFDGALNVDITEFQ
TNLVPYPRIHFMLSSYAPIISAEKAYHEQLSVAEITNSAFEPANMMAKCD
PRHGKYMACSMMYRGDVVPKDVNASIATIKTKRTIQFVDWCPTGFKVGIN
YQPPTVVPGGDLAKVMRAVCMISNSTAIAEVFSRLDHKFDLMYAKRAFVH
WYVGEGMEEGEFSEAREDLAALEKDYEEVGIET

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8sf7 Chain OI Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8sf7 Effect of alpha-tubulin acetylation on the doublet microtubule structure
• Resolution: 4.1 Å
• Binding residue (original residue number in PDB): E71 D98
• Binding residue (residue number reindexed from 1): E65 D92
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.5.-

Gene Ontology

Molecular Function

• GO:0005200 structural constituent of cytoskeleton
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000226 microtubule cytoskeleton organization
• GO:0000278 mitotic cell cycle

Cellular Component

• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005874 microtubule

External links

• PDB: RCSB:8sf7, PDBe:8sf7, PDBj:8sf7
• PDBsum: 8sf7
• PubMed: 38598282
• UniProt: P41351|TBA_TETTH Tubulin alpha chain