Structure of PDB 8rq2 Chain O Binding Site BS02

Receptor Information

>8rq2 Chain O (length=116) Species: 562 (Escherichia coli)

DKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAA
STVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHG
RVQALADAAREAGLQF

Ligand information

>8rq2 Chain B (length=120)

ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacuca
gaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgag
aguagggaacugccaggcaa

<<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>
>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>...
....>>...>>>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8rq2 Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88.
• Resolution: 2.44 Å
• Binding residue (original residue number in PDB): K3 K4 R15 R25 H29 R30 T31 P32 R33 H34 Y36 Q38 G44 V47 V54 E55 Y64 N67 K68 H100 G101 R102
• Binding residue (residue number reindexed from 1): K2 K3 R14 R24 H28 R29 T30 P31 R32 H33 Y35 Q37 G43 V46 V53 E54 Y63 N66 K67 H99 G100 R101

Gene Ontology

Molecular Function

• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8rq2, PDBe:8rq2, PDBj:8rq2
• PDBsum: 8rq2
• PubMed: 38730238
• UniProt: P0C018|RL18_ECOLI Large ribosomal subunit protein uL18 (Gene Name=rplR)