Structure of PDB 8qbt Chain O Binding Site BS02

Receptor Information

>8qbt Chain O (length=114) Species: 679895 (Escherichia coli BW25113)

KSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAAST
VEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHGRV
QALADAAREAGLQF

Ligand information

>8qbt Chain B (length=118)

gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucag
aagugaaacgccguagcgccgaugguaguguggggucuccccaugcgaga
guagggaacugccaggca

<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>
..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>....
...>>...>>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8qbt Novel arrest peptides induce ribosome stalling by short circuiting the ribosomal peptidyltransferase activity
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): R15 R25 H29 R30 T31 P32 R33 H34 Y36 Q38 I40 G44 S45 E46 V47 V54 K63 Y64 N67 K68 Q98 H100 G101 R102
• Binding residue (residue number reindexed from 1): R12 R22 H26 R27 T28 P29 R30 H31 Y33 Q35 I37 G41 S42 E43 V44 V51 K60 Y61 N64 K65 Q95 H97 G98 R99

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8qbt, PDBe:8qbt, PDBj:8qbt
• PDBsum: 8qbt
• PubMed: 38503735
• UniProt: P0C018|RL18_ECOLI Large ribosomal subunit protein uL18 (Gene Name=rplR)