Structure of PDB 8oop Chain O Binding Site BS02

Receptor Information
>8oop Chain O (length=109) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTA
EILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPN
IQAVLLPKK
Ligand information
>8oop Chain L (length=107) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agtaatccccttggcggttaaaacgcgggggacagcgcgtacgtgcgttt
aagcggtgctagagcttgctacgaccaattgagcggcctcggcaccggga
ttctcca
Receptor-Ligand Complex Structure
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PDB8oop Hexasome-INO80 complex reveals structural basis of noncanonical nucleosome remodeling.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		R11 K13 R29 R42 V43 G44 A45 K75 T76 R77 K118
Binding residue
(residue number reindexed from 1)		R1 K3 R19 R32 V33 G34 A35 K65 T66 R67 K108
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8oop, PDBe:8oop, PDBj:8oop
PDBsum8oop
PubMed37384673
UniProtQ93077|H2A1C_HUMAN Histone H2A type 1-C (Gene Name=H2AC6)

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