Structure of PDB 8asc Chain O Binding Site BS02

Receptor Information
>8asc Chain O (length=498) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGRDSLIFLVDASKAMFESQSEDELTPFDMSIQCIQSVYISKIISSDRDL
LAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELDQFKGQQGQKRFQ
DMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDSAK
ASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISILRVHFEESS
KLEDLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIK
LYRETNEPVKTKTRTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEEL
KRFDDPGLMLMGFKPLVLLKKHHYLRPSLFVYPEESLVIGSSTLFSALLI
KCLEKEVAALCRYTPRRNIPPYFVALVPQEEELDDQKIQVTPPGFQLVFL
PFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFENPVLQQHF
RNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYN
Ligand information
Receptor-Ligand Complex Structure
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PDB8asc PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		S33 A255 S257 R258 L281 P285 T300 R403
Binding residue
(residue number reindexed from 1)		S1 A218 S220 R221 L244 P248 T263 R366
Enzymatic activity
Enzyme Commision number 3.6.4.-
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0042162 telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0006303 double-strand break repair via nonhomologous end joining
Cellular Component
GO:0005634 nucleus
GO:0043564 Ku70:Ku80 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8asc, PDBe:8asc, PDBj:8asc
PDBsum8asc
PubMed37256950
UniProtP12956|XRCC6_HUMAN X-ray repair cross-complementing protein 6 (Gene Name=XRCC6)

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