Structure of PDB 6xz7 Chain O Binding Site BS02

Receptor Information

>6xz7 Chain O (length=117) Species: 83333 (Escherichia coli K-12)

MDKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVA
ASTVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYH
GRVQALADAAREAGLQF

Ligand information

>6xz7 Chain B (length=120)

ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacuca
gaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgag
aguagggaacugccaggcau

<<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>
>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>...
....>>...>>>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6xz7 Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to theE. coli70S ribosome.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): K3 R15 R25 H29 R30 T31 P32 R33 H34 Y36 Q38 G44 S45 E46 V47 V54 E55 K56 K63 Y64 N67 K68 H100 G101 R102
• Binding residue (residue number reindexed from 1): K3 R15 R25 H29 R30 T31 P32 R33 H34 Y36 Q38 G44 S45 E46 V47 V54 E55 K56 K63 Y64 N67 K68 H100 G101 R102

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6xz7, PDBe:6xz7, PDBj:6xz7
• PDBsum: 6xz7
• PubMed: 32144191
• UniProt: P0C018|RL18_ECOLI Large ribosomal subunit protein uL18 (Gene Name=rplR)