Structure of PDB 6rny Chain O Binding Site BS02

Receptor Information
>6rny Chain O (length=338) Species: 11963 (Human spumaretrovirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVSRPEGVKIIPPQSDRQKIVLQAHNLAHTGREATLLKIANLYWWPNMRK
DVVKQLGRCQQCLITNASNKASGPILRPDRPQKPFDKFFIDYIGPLPPSQ
GYLYVLVVVDGMTGFTWLYPTKAPSTSATVKSLNVLTSIAIPKVIHSDQG
AAFTSSTFAEWAKERGIHLEFSTPYHPQSSGKVERKNSDIKRLLTKLLVG
RPTKWYDLLPVVQLALNNTYSPVLKYTPHQLLFGIDSNTPFANQDTLDLT
REEELSLLQEIRTSLYHPSTPPASSRSWSPVVGQLVQERVARPASLRPRW
HKPSTVLKVLNPRTVVILDHLGNNRTVSIDNLKPTSHQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6rny Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		D185 Q186 Y212 R329
Binding residue
(residue number reindexed from 1)		D148 Q149 Y175 R292
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6rny, PDBe:6rny, PDBj:6rny
PDBsum6rny
PubMed31519882
UniProtP14350|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)

[Back to BioLiP]