Structure of PDB 6om6 Chain O Binding Site BS02

Receptor Information

>6om6 Chain O (length=116) Species: 562 (Escherichia coli)

DKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAA
STVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHG
RVQALADAAREAGLQF

Ligand information

>6om6 Chain 3 (length=120)

ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacuca
gaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgag
aguagggaacugccaggcau

<<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>
>..>>>...>>>>>>.>>.<<...<...<<<<<<<<...>>>>>>>>...
..>.>>...>>>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6om6 trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): K3 R25 R30 T31 R33 H34 Y36 G44 S45 E46 V54 K56 Y64 N67 K68 H100 R102
• Binding residue (residue number reindexed from 1): K2 R24 R29 T30 R32 H33 Y35 G43 S44 E45 V53 K55 Y63 N66 K67 H99 R101

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6om6, PDBe:6om6, PDBj:6om6
• PDBsum: 6om6
• PubMed: 33741965
• UniProt: P0C018|RL18_ECOLI Large ribosomal subunit protein uL18 (Gene Name=rplR)