Structure of PDB 6bk8 Chain O Binding Site BS02

Receptor Information
>6bk8 Chain O (length=229) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NIHIPRYIRNQPWYYKYLVHHRQLDIDNNSEPKIGMGIKDEFKLIFCRNC
GEAGHKEKDCMEKPRKMVLVRATDDDWDSRKDRWYGYSGKEYNELISKWE
RDKRNKIDEEIELMKLELYKDSLYRTSTRLREDKAAYLNDINSTESNYDP
KSRLYKTETLGAVDEKSKMFRRHLTGEGLKLNELNQFARSHAKEMGIRDE
IEDKEKVQHVLVANPTKYEYLKKKREQEE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6bk8 Chain O Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6bk8 Structure of the yeast spliceosomal postcatalytic P complex.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		C122 C125 H130 C135
Binding residue
(residue number reindexed from 1)		C47 C50 H55 C60
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000386 second spliceosomal transesterification activity
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
GO:0030628 pre-mRNA 3'-splice site binding
GO:0046872 metal ion binding
Biological Process
GO:0000350 generation of catalytic spliceosome for second transesterification step
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0071021 U2-type post-spliceosomal complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bk8, PDBe:6bk8, PDBj:6bk8
PDBsum6bk8
PubMed29146870
UniProtQ02775|SLU7_YEAST Pre-mRNA-splicing factor SLU7 (Gene Name=SLU7)

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