Structure of PDB 5z86 Chain O Binding Site BS02

Receptor Information
>5z86 Chain O (length=227) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAYPMQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKL
THTSTMDAQEVETIWTILPAIILILIALPSLRILYMMDEINNPSLTVKTM
GHQWYWSYEYTDYEDLSFDSYMIPTSELKPGELRLLEVDNRVVLPMEMTI
RMLVSSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMSSRPGLYYGQCSEIC
GSNHSFMPIVLELVPLKYFEKWSASML
Ligand information
Ligand IDCUA
InChIInChI=1S/2Cu
InChIKeyALKZAGKDWUSJED-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cu][Cu]
FormulaCu2
NameDINUCLEAR COPPER ION
ChEMBL
DrugBank
ZINC
PDB chain5z86 Chain O Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5z86 X-ray structural analyses of azide-bound cytochromecoxidases reveal that the H-pathway is critically important for the proton-pumping activity.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		H161 C196 E198 C200 H204 M207
Binding residue
(residue number reindexed from 1)		H161 C196 E198 C200 H204 M207
Annotation score1
Enzymatic activity
Enzyme Commision number 7.1.1.9: cytochrome-c oxidase.
Gene Ontology
Molecular Function
GO:0004129 cytochrome-c oxidase activity
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0022900 electron transport chain
GO:0042773 ATP synthesis coupled electron transport
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0045277 respiratory chain complex IV

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5z86, PDBe:5z86, PDBj:5z86
PDBsum5z86
PubMed30077971
UniProtP68530|COX2_BOVIN Cytochrome c oxidase subunit 2 (Gene Name=MT-CO2)

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