Structure of PDB 5t2a Chain O Binding Site BS02

Receptor Information
>5t2a Chain O (length=203) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GAFMYLNELWKKKSSDVMRFIQRIRSWEFRHQHTVVRLRRPTRPEKARML
GYKTKQGFCVFRVRVRRGGRKRPVHKGITYGKPKTSGVLGMKLNKNNQAV
AEQRLGKRFGNLRVLNSYWVNMDSTFKWYEVIAVDPMCKTIRRDPRINWI
VNSVHKHREQRGLTSAGRKHRGLRHKGHKASKLRPSYRAAWRRNNRIVFL
RKR
Ligand information
>5t2a Chain B (length=1064) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccaacugcagaccguacucaucaccgcaucagguccccaagcauagaau
gcucugguacauagagaaagguacacucagggaagucggcaaaauagaug
cguaaguucgcaagaagcauuggcucugagggcaauugccaacucagaac
ugcuuacggcggggaauccaacuguauaauuaaaacauagguuugugaug
cauccaagugguguauaucgcaaacugauuucugcccagugcucugaaug
ucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacuau
gacucucuuaagguagccaaaugccucgucuuccaauuagagacgcgcau
gaauggauuaaugagauucccucugucccgaguuacuaucuagcgaaacg
acagucaagggaacggacuugaagggcuaagcggggaaagaagacccugu
ugaguuugacuccagucuggcucugugcggcgacguugcuucacuuaucg
aaugaagagaccaaugggcgugcuguaaacugaaccaacggguccggagu
cuuguuucgagacaucugccagauggggaguuuggcuggggcggcauauc
uguuacacgacaacgcagguguccuaaggcgagcucagugggaacagaaa
ucucacguagaacacaagcguaaaagcuugcuugauuaacgauuuccagu
acgaaucgagacugcgaaagcaaggccagcgauccuuugcgaagaauagg
aaauaugaacaaaucauaccagaggugucagaauaauuaccacagggaua
acuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuu
cgaugucggcucuuccuaaccuagcgccgcagaagacgcuaaggguugga
uuguucacccacugacagggaacgugagcuggguuuagaccgucgugaga
cagguugguuuuacccuacuuagcuggaaauugcgagaaaagauuauccg
cgcaaagcggaggcaguccgucugggucugccguucgguggcaugugcuu
ggcgcugccaucuc
........................<<......>>......<<<<.....>
>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<
<...............>>>>><<.<<<<<<<<<<..>>>>..>>>>>>.>
>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....
<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<
<....<<<<......>>>>....>>..>>>>..>>>>><<<<<<......
.>>>>>>........<...........<<<<<.......>>>>>.....>
.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>........
....<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.
<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<..>>>>>.>>>...<<<
<<.....<<<<...........................<<<..>>>..>>
>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..<<<
<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......
>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.....
..>>>>>..>>.<<<....>>>.>>........<<<<<<...........
...<<<<.......>>>>.>>>>>>.........>>>>..>>>>>>....
...<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>..
.....<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.
........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>
>.>>>>....>>..>>>.>>>>>>>......................<<<
<.....>>>>.<<<<<<<<....>>>.>>>>>....<<<<<<<..<....
...>.>>>>>>>..
Receptor-Ligand Complex Structure
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PDB5t2a Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		R24 W28 R67 K72 P74 H76 K77 I79 G82 S87 V89 L90 S125 T126
Binding residue
(residue number reindexed from 1)		R23 W27 R66 K71 P73 H75 K76 I78 G81 S86 V88 L89 S124 T125
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5t2a, PDBe:5t2a, PDBj:5t2a
PDBsum5t2a
PubMed27752045
UniProtE9BMB4

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