Structure of PDB 5nrl Chain O Binding Site BS02

Receptor Information
>5nrl Chain O (length=833) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLMFFKPSDHKYFADVISNKDEKKERTLSMLLLKIKNGNTASRRTSMRIL
TDKAVTFGPEMIFNRLLPILLDRSLEDQERHLMIKTIDRVLYQLGDLTKP
YVHKILVVAAPLLIDEDPMVRSTGQEIITNLSTVAGLKTILTVMRPDIEN
EDEYVRNVTSRAAAVVAKALGVNQLLPFINAACHSRKSWKARHTGIKIVQ
QIGILLGIGVLNHLTGLMSCIKDCLMDDHVPVRIVTAHTLSTLAENSYPY
GIEVFNVVLEPLWKGIRSHRGKVLSSFLKAVGSMIPLMDPEYAGYYTTEA
MRIIRREFDSPDDEMKKTILLVLQKCSAVESITPKFLREEIAPEFFQKFW
VRRVALDRPLNKVVTYTTVTLAKKLGCSYTIDKLLTPLRDEAEPFRTMAV
HAVTRTVNLLGTADLDERLETRLIDALLIAFQEQTNSDSIIFKGFGAVTV
SLDIRMKPFLAPIVSTILNHLKHKTPLVRQHAADLCAILIPVIKNCHEFE
MLNKLNIILYESLGEVYPEVLGSIINAMYCITSVMDLDKLQPPINQILPT
LTPILRNKHRKVEVNTIKFVGLIGKLAPTYAPPKEWMRICFELLELLKST
NKEIRRSANATFGFIAEAIGPHDVLVALLNNLKVQERQLRVCTAVAIGIV
AKVCGPYNVLPVIMNEYTTPETNVQNGVLKAMSFMFEYIGNMSKDYIYFI
TPLLEDALTDRDLVHRQTASNVITHLALNCSGTGHEDAFIHLMNLLIPNI
FETSPHAIMRILEGLEALSQALGPGLFMNYIWAGLFHPAKNVRKAFWRVY
NNMYVMYQDAMVPFYPVTPDNNEEYIEELDLVL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5nrl Structure of a pre-catalytic spliceosome.
Resolution7.2 Å
Binding residue
(original residue number in PDB)		R496 N499 K500 T535 M536 H539 R698 T738 K740 R744 Q773 R775 R778 V779 V783 N811 K818 Y826 V852 Q855 H894 R898
Binding residue
(residue number reindexed from 1)		R358 N361 K362 T397 M398 H401 R560 T600 K602 R606 Q635 R637 R640 V641 V645 N673 K680 Y688 V714 Q717 H756 R760
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0005515 protein binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0071004 U2-type prespliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5nrl, PDBe:5nrl, PDBj:5nrl
PDBsum5nrl
PubMed28530653
UniProtP49955|SF3B1_YEAST U2 snRNP component HSH155 (Gene Name=HSH155)

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