Structure of PDB 5flx Chain O Binding Site BS02

Receptor Information
>5flx Chain O (length=136) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLGPQVAEGENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMKVKAD
RDESSPYAAMLAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQSA
LRALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL
Ligand information
>5flx Chain z (length=264) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccugugaggaacuacugucuucacgcagaaagcgucuagccauggcguua
guaugagugucgugcagccuccaggacccccccucccgggagagccauag
uggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgc
aagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugc
cugauagggugcuugcgagugccccgggaggucucguagaccgugcacca
ugagcacgaauccu
<<<<.<<<<.....<<<<<..<<<.<<....<<<<<.......>>>>>..
...>>.>>>..>.>>>>>>>>>>>>......<<<<<<<<<<<.<<<<<<<
<<<<<<<<<<..<<<<<......>>>>><<<.>>>.<<<....>>>>>>>
.>>>>>>>>><<<.....<<<......>>>....>>>....>>>>.>><<
<<....>>>><<..(((((.>>>>>>>>>>>.))))).............
..............
Receptor-Ligand Complex Structure
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PDB5flx Molecular Architecture of the Ribosome-Bound Hepatitis C Virus Internal Ribosomal Entry Site RNA.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		D67 S70 Y72 L151
Binding residue
(residue number reindexed from 1)		D52 S55 Y57 L136
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0045182 translation regulator activity
GO:0048027 mRNA 5'-UTR binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006417 regulation of translation
GO:0030218 erythrocyte differentiation
GO:0030490 maturation of SSU-rRNA
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0014069 postsynaptic density
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5flx, PDBe:5flx, PDBj:5flx
PDBsum5flx
PubMed26604301
UniProtP62263|RS14_HUMAN Small ribosomal subunit protein uS11 (Gene Name=RPS14)

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