Structure of PDB 7mqa Chain NH Binding Site BS02

Receptor Information
>7mqa Chain NH (length=1066) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EILFHSSLLRLQVEELLKEVRLSEKKKDRIDAFLREVNQRVVRVPSVPET
ELTDQAWLPAGVRVPLHQVPYAVKGCFRFLPPAQVTVVGSYLLGTCIRPD
INVDVALTMPREILQDKDGLNQRYFRKRALYLAHLAHHLAQDPLFGSVCF
SYTNGCHLKPSLLLRPRGKDERLVTVRLHPCPPPDFFRPCRLLPTKNNVR
SAWYRGQSPAGDGSPEPPTPRYNTWVLQDTVLESHLQLLSTILSSAQGLK
DGVALLKVWLRQRELDKGQGGFTGFLVSMLVVFLVSTRKIHTTMSGYQVL
RSVLQFLATTDLTVNGISLCLSSDPSLPALADFHQAFSVVFLDSSGHLNL
CADVTASTYHQVQHEARLSMMLLDSRADDGFHLLLMTPKPMIRAFDHVLH
LRPLSRLQAACHRLKLWPELQDNGGDYVSAALGPLTTLLEQGLGARLNLL
AHSRPPVPEWDISQDPPKHKDSGTLTLGLLLRPEGLTSVLELGPEADQPE
AAKFRQFWGSRSELRRFQDGAIREAVVWEAASMSQKRLIPHQVVTHLLAL
HADIPETCVHYVGGPLDALIQGLKETSSTGEEALVAAVRCYDDLSRLLWG
LEGLPLTVSAVQGAHPVLRYTEVFPPTPVRPAFSFYETLRERSSLLPRLD
KPCPAYVEPMTVVCHLEGSGQWPQDAEAVQRVRAAFQLRLAELLTQQHGL
QCRATATHTDVLKDGFVFRIRVAYQREPQILKEVQSPEGMISLRDTAASL
RLERDTRQLPLLTSALHGLQQQHPAFSGVARLAKRWVRAQLLGEGFADES
LDLVAAALFLHPEPFTPPSSPQVGFLRFLFLVSTFDWKNNPLFVNLNNEL
TVEEQVEIRSGFLAARAQLPVMVIVTPQDRKNSVWTQDGPSAQILQQLVV
LAAEALPMLEKQLMDPRGPGDIRTVFRPPLDIYDVLIRLSPRHIPRHRQA
VDSPAASFCRGLLSQPGPSSLMPVLGYDPPQLYLTQLREAFGDLALFFYD
QHGGEVIGVLWKPTSFQPQPFKASSTKGRMVMSRGGELVMVPNVEAILED
FAVLGEGLVQTVEARS
Ligand information
Ligand IDATP
InChIInChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyZKHQWZAMYRWXGA-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
FormulaC10 H16 N5 O13 P3
NameADENOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL14249
DrugBankDB00171
ZINCZINC000004261765
PDB chain7mqa Chain NH Residue 3000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7mqa Nucleolar maturation of the human small subunit processome.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		G164 S165 N177 D179 R252 Q303 H310 F350 L425
Binding residue
(residue number reindexed from 1)		G89 S90 N102 D104 R177 Q228 H235 F275 L350
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0006364 rRNA processing
GO:0006409 tRNA export from nucleus
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0032040 small-subunit processome
GO:0032545 CURI complex
GO:0034456 UTP-C complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7mqa, PDBe:7mqa, PDBj:7mqa
PDBsum7mqa
PubMed34516797
UniProtQ9H6R4|NOL6_HUMAN Nucleolar protein 6 (Gene Name=NOL6)

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