Structure of PDB 8ovw Chain N Binding Site BS02

Receptor Information

>8ovw Chain N (length=391) Species: 4932 (Saccharomyces cerevisiae)

ELRLEDNYVPTSDTLVVFKQLMKLPVTVLYDLTLSWFAKFGGSFDGDIYL
LTETLDLLIEKGVRRNVIVNRILYVYWPDGLNVFQLAEIDCHLMISKPEK
FKWLPSKALRGDGKPYVVKLQPAKFIENLQTDLAKIYHCHVYMFKHPSLP
VLITRIQLFDSNLDKFQGKPLISRRPYYVAFPLNSPIIFHSVDKDIYARL
VLQSISRTISERETIIFKPVQKIPVKSIHNIMTLLGPSRFAESMGPWECY
ASANFERSPLHDYKKHQGLTGKKVMVREFDDSFLNDGKEEPEIRRLRLEK
NMIKFKGSANGVMSRYSSLVPIEKVGFTLKNEINSRIITIKLKFNGNDIF
GGLHELCDKNLINIDKVPGWLAGENGSFSGTIMNGDFQREQ

Ligand information

>8ovw Chain E (length=27)

taagtcacatggtgccgaggccgctca

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ovw Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): K105 K384 N405
• Binding residue (residue number reindexed from 1): K102 K324 N345

Gene Ontology

Molecular Function

• GO:0005198 structural molecule activity

Biological Process

• GO:0007059 chromosome segregation
• GO:0007094 mitotic spindle assembly checkpoint signaling
• GO:0008608 attachment of spindle microtubules to kinetochore
• GO:0034080 CENP-A containing chromatin assembly
• GO:0034087 establishment of mitotic sister chromatid cohesion
• GO:0034089 establishment of meiotic sister chromatid cohesion
• GO:0034090 maintenance of meiotic sister chromatid cohesion
• GO:0051301 cell division
• GO:0051321 meiotic cell cycle
• GO:0051382 kinetochore assembly
• GO:0071459 protein localization to chromosome, centromeric region

Cellular Component

• GO:0000775 chromosome, centromeric region
• GO:0000776 kinetochore
• GO:0000940 outer kinetochore
• GO:0005634 nucleus
• GO:0005694 chromosome

External links

• PDB: RCSB:8ovw, PDBe:8ovw, PDBj:8ovw
• PDBsum: 8ovw
• PubMed: 37506202
• UniProt: P38907|CENPN_YEAST Inner kinetochore subunit CHL4 (Gene Name=CHL4)