Structure of PDB 7o3h Chain N Binding Site BS02

Receptor Information
>7o3h Chain N (length=380) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTNMRKTHPLFKIINHSFIDLPAPSNISSWWNFGSLLGVCLMVQIITGLF
LAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGR
GLYYGSYTFMETWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLL
SAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAIVHLLFL
HETGSNNPTGLNSDADKIPFHPYYTIKDILGILIMFLILMTLVLFFPDML
GDPDNYMPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILI
LALMPFLHTSKQRSLMFRPITQILYWILVANLLILTWIGGQPVEHPFIII
GQLASISYFSIILILMPISGIIEDKMLKLY
Ligand information
Ligand IDHEM
InChIInChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;
InChIKeyKABFMIBPWCXCRK-RGGAHWMASA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6Cc1c2n3c(c1CCC(=O)O)C=C4C(=C(C5=[N]4[Fe]36[N]7=C(C=C8N6C(=C5)C(=C8C)C=C)C(=C(C7=C2)C)C=C)C)CCC(=O)O
CACTVS 3.385CC1=C(CCC(O)=O)C2=Cc3n4[Fe]5|6|N2=C1C=c7n5c(=CC8=N|6C(=Cc4c(C)c3CCC(O)=O)C(=C8C=C)C)c(C)c7C=C
ACDLabs 12.01C=1c3c(c(c4C=C5C(=C(C=6C=C7C(=C(C8=CC=2C(=C(C=1N=2[Fe](n34)(N5=6)N78)CCC(=O)O)C)\C=C)C)\C=C)C)C)CCC(=O)O
FormulaC34 H32 Fe N4 O4
NamePROTOPORPHYRIN IX CONTAINING FE;
HEME
ChEMBL
DrugBankDB18267
ZINC
PDB chain7o3h Chain N Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7o3h Structure and assembly of the mammalian mitochondrial supercomplex CIII 2 CIV.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		W31 L37 H97 V98 R100 S106 W113 G116 H196 L200 S205 N206
Binding residue
(residue number reindexed from 1)		W31 L37 H97 V98 R100 S106 W113 G116 H196 L200 S205 N206
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008121 ubiquinol-cytochrome-c reductase activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0044877 protein-containing complex binding
GO:0046872 metal ion binding
Biological Process
GO:0001666 response to hypoxia
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
GO:0007584 response to nutrient
GO:0009410 response to xenobiotic stimulus
GO:0009636 response to toxic substance
GO:0009725 response to hormone
GO:0014070 response to organic cyclic compound
GO:0015990 electron transport coupled proton transport
GO:0022904 respiratory electron transport chain
GO:0031100 animal organ regeneration
GO:0033590 response to cobalamin
GO:0033762 response to glucagon
GO:0045333 cellular respiration
GO:0045471 response to ethanol
GO:0046686 response to cadmium ion
GO:0046688 response to copper ion
GO:0046689 response to mercury ion
GO:0051592 response to calcium ion
GO:0055093 response to hyperoxia
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0045275 respiratory chain complex III

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7o3h, PDBe:7o3h, PDBj:7o3h
PDBsum7o3h
PubMed34616041
UniProtP00158|CYB_MOUSE Cytochrome b (Gene Name=Mt-Cyb)

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