Structure of PDB 6l49 Chain N Binding Site BS02

Receptor Information
>6l49 Chain N (length=95) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSRKESYSIYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRL
AHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSAK
Ligand information
>6l49 Chain J (length=485) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcgatgtatatatctgacacgtgcctggagactagggagtaatcccctt
ggcggttaaaacgcgggggacagcgcgtacgtgcgtttaagcggtgctag
agctgtctacgaccaattgagcggcctcggcaccgggattctgattatcc
aggccgttggggcctatccaatcgatgtatatatctgacacgtgcctgga
gactagggagtaatccccttggcggttaaaacgcgggggacagcgcgtac
gtgcgtttaagcggtgctagagctgtctacgaccaattgagcggcctcgg
caccgggattctgattatccaggccgtccgggcctatccaatcgatgtat
atatctgacacgtgcctggagactagggagtaatccccttggcggttaaa
acgcgggggacagcgcgtacgtgcgtttaagcggtgctagagctgtctac
gaccaattgagcggcctcggcaccgggattctgat
Receptor-Ligand Complex Structure
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PDB6l49 Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome.
Resolution18.9 Å
Binding residue
(original residue number in PDB)		R28 R30 K31 E32 S33 I36 Y37
Binding residue
(residue number reindexed from 1)		R1 R3 K4 E5 S6 I9 Y10
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001530 lipopolysaccharide binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Biological Process
GO:0002227 innate immune response in mucosa
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0019731 antibacterial humoral response
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0061644 protein localization to CENP-A containing chromatin
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Cellular Component
GO:0000786 nucleosome
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0043505 CENP-A containing nucleosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6l49, PDBe:6l49, PDBj:6l49
PDBsum6l49
PubMed31711756
UniProtP06899|H2B1J_HUMAN Histone H2B type 1-J (Gene Name=H2BC11)

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