Structure of PDB 6g63 Chain N Binding Site BS02

Receptor Information
>6g63 Chain N (length=494) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKRMLINATQQEELRVALVDGQRLYDLDIESPGHEQKKANIYKGKITRIE
PSLEAAFVDYGAERHGFLPLKEIAREYFPRPNIKDVLREGQEVIVQIDKE
ERGNKGAALTTFISLAGSYLVLMPNNPRAGGISRRIELKEALASLELPEG
MGLIVRTAGVGKSAEALQWDLSFRLKHWEAIKKAAESRPAPFLIHQESNV
IVRAFRDYLRQDIGEILIDNPKVLELARQHIAALGRPDFSSKIKLYTGEI
PLFSHYQIESQIESAFQREVRLPSGGSIVIDSTEALTAIRINSARATDIE
ETAFNTNLEAADEIARQLRLRDLGGLIVIRFIDMTPVRHQRAVENRLREA
VRQDRARIQISHISRFGLLEMSRQRLSPSLGESSHHVCPRCSGTGTVRDN
ESLSLSILRLIEEEALKENTQEVHAIVPVPIASYLLNEKRSAVNAIETRQ
DGVRCVIVPNDQMETPHYHVLRVRKGEETPTLSYMLPKLHEEAM
Ligand information
Ligand IDU
InChIInChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKeyDJJCXFVJDGTHFX-XVFCMESISA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C1NC(=O)N(C=C1)C2OC(C(O)C2O)COP(=O)(O)O
CACTVS 3.341O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.5.0C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O
OpenEye OEToolkits 1.5.0C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)O)O)O
CACTVS 3.341O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(O)=O)N2C=CC(=O)NC2=O
FormulaC9 H13 N2 O9 P
NameURIDINE-5'-MONOPHOSPHATE
ChEMBLCHEMBL214393
DrugBankDB03685
ZINCZINC000002123545
PDB chain6g63 Chain N Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6g63 Substrate Recognition and Autoinhibition in the Central Ribonuclease RNase E.
Resolution3.95 Å
Binding residue
(original residue number in PDB)		V128 S140 R142 I167 R169 T170 R223 R371
Binding residue
(residue number reindexed from 1)		V121 S133 R135 I154 R156 T157 R210 R355
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.12: ribonuclease E.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004540 RNA nuclease activity
GO:0008995 ribonuclease E activity
Biological Process
GO:0006396 RNA processing

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6g63, PDBe:6g63, PDBj:6g63
PDBsum6g63
PubMed30270108
UniProtP21513|RNE_ECOLI Ribonuclease E (Gene Name=rne)

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