Structure of PDB 6exn Chain N Binding Site BS02

Receptor Information
>6exn Chain N (length=242) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPPPNICEQCLGDEANIRMTKIPQGSECKICTLPFTLYHFKTSKRSNNII
KTLICVRCATQRNICQCCMLDSRWHIPIQLRDHLISLVNEENVMTEEAKN
DMMKRFLSLKNVKLGGAQITSDPSEADNIVDKLKNILLRKSFFLYNIDAS
IPEWKITDTVSQLLGILSLIVNHKAKCGGLRFQSSELGERFVSKIRGVLL
IDRFRIFIIPWSSGFSAASFGTNTAENIKLSLSLNKLIQLEL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6exn Chain N Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6exn Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		C34 C37 C64
Binding residue
(residue number reindexed from 1)		C28 C31 C58
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0017070 U6 snRNA binding
GO:0036002 pre-mRNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0071006 U2-type catalytic step 1 spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6exn, PDBe:6exn, PDBj:6exn
PDBsum6exn
PubMed29146871
UniProtP38241|SLT11_YEAST Pre-mRNA-splicing factor SLT11 (Gene Name=ECM2)

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