Structure of PDB 3aoh Chain N Binding Site BS02

Receptor Information
>3aoh Chain N (length=1351) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERDGLFDERIFG
PIKDYECACGKYKRQRFEGKVCERCGVEVTKSIVRRYRMGHIELATPAAH
IWFVKDVPSKIGTLLDLSATELEQVLYFSKYIVLDPKGAILNGVPVEKRQ
LLTDEEYRELRYGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDG
VALYRFPRRVRVEYEPKDYRVQPHMNVVVPEGARVEAGDKIVAAIDPEEE
VIAEAEGVVHLHEPASILVVKARVYPFEDDVEVSTGDRVAPGDVLADGGK
VKSDVYGRVEVDLVRNVVRVVESYDIDARMGAEAIQQLLKELDLEALEKE
LLEEMKHPSRARRAKARKRLEVVRAFLDSGNRPEWMILEAVPVLPPDLRP
TSDLNDLYRRLINRNNRLKKLLAQGAPEIIIRNEKRMLQEAVDALLDNGR
RGAPVTNPGSDRPLRSLTDILSGKQGRFRQNLLGKRVDYSGRSVIVVGPQ
LKLHQCGLPKRMALELFKPFLLKKMEEKGIAPNVKAARRMLERQRDIKDE
VWDALEEVIHGKVVLLNRAPTLHRLGIQAFQPVLVEGQSIQLHPLVCEAF
NADFDGDQMAVHVPLSSFAQAEARIQMLSAHNLLSPASGEPLAKPSRDII
LGLYYITQVRKEKKGAGLEFATPEEALAAHERGEVALNAPIKVAGRETSV
GRLKYVFANPDEALLAVAHGIVDLQDVVTVRYMGKRLETSPGRILFARIV
AEAVEDEKVAWELIQLDVPQEKNSLKDLVYQAFLRLGMEKTARLLDALKY
YGFTFSTTSGITIGIDDAVIPEEKKQYLEEADRKLLQIEQAYEMGFLTDR
ERYDQILQLWTETTEKVTQAVFKNFEENYPFNPLYVMAQSGARGNPQQIR
QLCGLRGLMQKPSGETFEVPVRSSFREGLTVLEYFISSHGARKGGADTAL
RTADSGYLTRKLVDVTHEIVVREADCGTTNYISVPLFQPDEVTRSLRLRK
RADIEAGLYGRVLAREVEVLGVRLEEGRYLSMDDVHLLIKAAEAGEIQEV
PVRSPLTCQTRYGVCQKCYGYDLSMARPVSIGEAVGIVAAQSIGEPGTQL
TTQGLPRVIELFEARRPKAKAVISEIDGVVRIEETEEKLSVFVESEGFSK
EYKLPKEARLLVKDGDYVEAGQPLTRGAIDPHQLLEAKGPEAVERYLVEE
IQKVYRAQGVKLHDKHIEIVVRQMMKYVEVTDPGDSRLLEGQVLEKWDVE
ALNERLIAEGKTPVAWKPLLMGVTKSALSTKSWLSAASFQNTTHVLTEAA
IAGKKDELIGLKENVILGRLIPAGTGSDFVRFTQVVDQKTLKAIEEARKE
A
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3aoh Chain N Residue 2006 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3aoh Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein
Resolution4.1 Å
Binding residue
(original residue number in PDB)		D741 D743
Binding residue
(residue number reindexed from 1)		D605 D607
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3aoh, PDBe:3aoh, PDBj:3aoh
PDBsum3aoh
PubMed21124318
UniProtQ8RQE8|RPOC_THET8 DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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