Structure of PDB 1owr Chain N Binding Site BS02

Receptor Information
>1owr Chain N (length=284) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQ
LHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVG
NTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRL
VFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQ
QMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPE
YRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1owr Structure of NFAT Bound to DNA as a Monomer
Resolution3.0 Å
Binding residue
(original residue number in PDB)		Y424 T426 K520 R522 N523 R537 K538
Binding residue
(residue number reindexed from 1)		Y30 T32 K126 R128 N129 R143 K144
Binding affinityPDBbind-CN: Kd=2.7nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1owr, PDBe:1owr, PDBj:1owr
PDBsum1owr
PubMed14643663
UniProtQ13469|NFAC2_HUMAN Nuclear factor of activated T-cells, cytoplasmic 2 (Gene Name=NFATC2)

[Back to BioLiP]