Structure of PDB 8dh5 Chain M Binding Site BS02

Receptor Information
>8dh5 Chain M (length=740) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNTINIAKNDFSDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEAR
FRKMFERQLKAGEVADNAAAKPLITTLLPKMIARINDWKPEAVAYITIKT
TLACLTNTTVQAVASAIGRAIEDEARFHKEDSIHVGVRCIEMLIESTIEL
APEYAEAIATRAGALAGISPMFQPCVVPPKPWTGITGGGYWANGRRPLAL
VRTHSKKALMRYEDVYMPEVYKAINIAQNTAWKINKKVLAVANVITKWKH
CPVEDIPAIEALTAWKRAAAAVYRKDKARKSRRISLEFMLEQANKFANHK
AIWFPYNMDWRGRVYAVSMFNPQGNDMTKGLLTLAKGKPIGKEGYYWLKI
HGANCAGVDKVPFPERIKFIEENHENIMACAKSPLENTWWAEQDSPFCFL
AFCFEYAGVQHHGLSYNCSLPLAFDGSCSGIQHFSAMLRDEVGGRAVNLL
PSETVQDIYGIVAKKVNEILQADAINGTDNLGTKALAGQWLAYGVTRSVT
KRSVMTLAYGSKEFGFRQQVLEDTIQPAIDSGKGLMFTQPNQAAGYMAKL
IWESVSVTVVAAVEAMNWLKSAAKLLAAEVKDKKTGEILRKRCAVHWVTP
DGFPVWQEYKKPIQTRLNLMFLGDSEIDAHKQESGIAPNFVHSQDGSHLR
KTVVWAHEKYGIESFALIHDSFGTIPADAANLFKAVRETMVDTYESCDVL
ADFYDQFADQLHESQLDKMPALPAKGNLNLRDILESDFAF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8dh5 Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		K389 A390 S393 R394 R425 G436 Y639 L752 I810 H811 D812
Binding residue
(residue number reindexed from 1)		K277 A278 S281 R282 R313 G324 Y509 L622 I668 H669 D670
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8dh5, PDBe:8dh5, PDBj:8dh5
PDBsum8dh5
PubMed36635281
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

[Back to BioLiP]