Structure of PDB 8ca7 Chain M Binding Site BS02

Receptor Information

>8ca7 Chain M (length=113) Species: 679895 (Escherichia coli BW25113)

ARIAGINIPDHKHAVIALTSIYGVGKTRSKAILAAAGIAEDVKISELSEG
QIDTLRDEVAKFVVEGDLRREISMSIKRLMDLGCYRGLRHRRGLPVRGQR
TKTNARTRKGPRK

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8ca7 Chain M Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ca7 Structural conservation of antibiotic interaction with ribosomes.
• Resolution: 2.06 Å
• Binding residue (original residue number in PDB): T20 I22 V25
• Binding residue (residue number reindexed from 1): T19 I21 V24
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8ca7, PDBe:8ca7, PDBj:8ca7
• PDBsum: 8ca7
• PubMed: 37550453
• UniProt: P0A7S9|RS13_ECOLI Small ribosomal subunit protein uS13 (Gene Name=rpsM)