Structure of PDB 7xd8 Chain M Binding Site BS02

Receptor Information
>7xd8 Chain M (length=624) Species: 11060 (dengue virus type 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGS
ASSMVNGVVRLLTKPWDIIPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEP
KEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDE
NKWKSAREAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFG
KAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLG
YILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAE
AIFKLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVVTYGLNTFTNME
AQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDCV
VKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHEL
IMKDGRVLVVPCRNQDELIGRARISQGAGWSLRETACLGKSYAQMWSLMY
FHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRV
WIQENPWMEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTA
INQVRSLIGNEEYTDYMPSMKRFR
Ligand information
Receptor-Ligand Complex Structure
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PDB7xd8 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		S405 S661 D663 C709 S710 L754 Y758 M761 T790 S791 R792
Binding residue
(residue number reindexed from 1)		S139 S395 D397 C443 S444 L488 Y492 M495 T524 S525 R526
Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7xd8, PDBe:7xd8, PDBj:7xd8
PDBsum7xd8
PubMed36577062
UniProtQ91H74

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