Structure of PDB 7w5b Chain M Binding Site BS02

Receptor Information
>7w5b Chain M (length=130) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKKRKNPDLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPT
SNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRRRPYNDDADIDYINE
RNAKFNKKAERFYGKYTAEIKQNLERGTAV
Ligand information
>7w5b Chain H (length=140) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuuua
auaucguccucuaccgaggacaauauuaaggauuuuuggagcagggagcc
acgcaucgaccugguauugcaguaccuccaggaacggugc
...............................................<<<
<<<..<<<<<<....>>>>>>..>>>>>>...............<.....
.><<<<<<.<<<<<.............>>>>>..>>>>>>
Receptor-Ligand Complex Structure
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PDB7w5b Mechanism of exon ligation by human spliceosome.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		K116 Y196 S197 R198 R200 R214 K217 F218 K221 R224
Binding residue
(residue number reindexed from 1)		K3 Y83 S84 R85 R87 R101 K104 F105 K108 R111
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0001701 in utero embryonic development
GO:0006397 mRNA processing
GO:0007095 mitotic G2 DNA damage checkpoint signaling
GO:0007369 gastrulation
GO:0008284 positive regulation of cell population proliferation
GO:0008380 RNA splicing
GO:0048568 embryonic organ development
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0016607 nuclear speck
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0071014 post-mRNA release spliceosomal complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7w5b, PDBe:7w5b, PDBj:7w5b
PDBsum7w5b
PubMed35705093
UniProtO95926|SYF2_HUMAN Pre-mRNA-splicing factor SYF2 (Gene Name=SYF2)

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