Structure of PDB 7pfx Chain M Binding Site BS02

Receptor Information
>7pfx Chain M (length=109) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLP
NIQAVLLPK
Ligand information
>7pfx Chain J (length=177) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
catgcacttacatgcacaggatgtatatatgtgacacgtgcctggagact
agggagtaatccccttggcggttaaaacgcgggggacagcgcgtacgtgc
gtttaagcggtgctagagctgtctacgaccaattgagcggcctcggcacc
gggattctccagtggccagtggcggcc
Receptor-Ligand Complex Structure
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PDB7pfx Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		R11 A12 K15 R17 R20 G28 R32 R77
Binding residue
(residue number reindexed from 1)		R2 A3 K6 R8 R11 G19 R23 R68
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
GO:0061644 protein localization to CENP-A containing chromatin
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0043505 CENP-A containing nucleosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pfx, PDBe:7pfx, PDBj:7pfx
PDBsum7pfx
PubMed35581345
UniProtP04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)

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