Structure of PDB 7o73 Chain M Binding Site BS02

Receptor Information
>7o73 Chain M (length=308) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RGPNLNIVLTCPECKVYPPKIVERFSEGDVVCALCGLVLSDKLVDRVGEA
SNPLLDGNNLSTRIGKGETTDMRFTKELNKAQGKNVMDKKDNEVQAAFAK
ITMLCDAAELPKIVKDCAKEAYKLCHDEKTLKGKSMESIMAASILIGCRR
AEVARTFKEIQSLIHVKTKEFGKTLNIMKNILRGKSEDGKIDTDNMSGAQ
NLTYIPRFCSHLGLPMQVTTSAEYTAKKCKEIKEIAGKSPITIAVVSIYL
NILLFQIPITAAKVGQTLQVTEGTIKSGYKILYEHRDKLVDPQLIANGVV
SLDNLPGV
Ligand information
>7o73 Chain T (length=65) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atgtatgtacaacacacatcggaggtgaatcgaacgttccatagctatta
tatacacagcgtgct
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7o73 Structure of RNA polymerase II pre-initiation complex at 2.9 angstrom defines initial DNA opening.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		K112 K164 G165 G271 K272 T276 T305 T308
Binding residue
(residue number reindexed from 1)		K80 K132 G133 G237 K238 T242 T271 T274
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000993 RNA polymerase II complex binding
GO:0001139 RNA polymerase II complex recruiting activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0017025 TBP-class protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001113 transcription open complex formation at RNA polymerase II promoter
GO:0001174 transcriptional start site selection at RNA polymerase II promoter
GO:0006352 DNA-templated transcription initiation
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0010467 gene expression
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0070897 transcription preinitiation complex assembly
Cellular Component
GO:0005634 nucleus
GO:0097550 transcription preinitiation complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7o73, PDBe:7o73, PDBj:7o73
PDBsum7o73
PubMed34133942
UniProtP29055|TF2B_YEAST Transcription initiation factor IIB (Gene Name=SUA7)

[Back to BioLiP]