Structure of PDB 7lyb Chain M Binding Site BS02

Receptor Information
>7lyb Chain M (length=94) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLN
QKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7lyb Chain M Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7lyb Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.
Resolution3.28 Å
Binding residue
(original residue number in PDB)		C39 H41 C61
Binding residue
(residue number reindexed from 1)		C36 H38 C58
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0006974 DNA damage response

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7lyb, PDBe:7lyb, PDBj:7lyb
PDBsum7lyb
PubMed34321665
UniProtP38398|BRCA1_HUMAN Breast cancer type 1 susceptibility protein (Gene Name=BRCA1)

[Back to BioLiP]