Structure of PDB 7eu0 Chain M Binding Site BS02

Receptor Information
>7eu0 Chain M (length=1052) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TNRSTVKISNVPQTIVADELLRFLELHLGEDTVFALEIPTTRDNWKPRDF
ARVQFTTLEVKSRAQLLSSQSKLLFKTHNLRLSEAYDDIIPRPVDPRKRL
DDIVLTVGFPESDEKRFCALEKWDGVRCWILTEKRRVEFWVWESGDCYKI
EVRFEDIIETLSCCVNGDASEIDAFLLKLKYGPKVFKRVTDRYRFCKEDF
DFMWIRTTDFSGSKSIGTSTCFCLEVHNGSTMLDIFSGLPYYREDTLSLT
YVDGKTFASAAQIVPLLNAAILGLEFPYEILFQLNALVHAQKISLFAASD
MELIKILRGMSLETALVILKKLHQQSSICYDPVFFVKTQMASAYKRLTEQ
NIMSCQRAYVTPSKIYLLGPELETANYVVKNFAEHVSDFMRVTFVEEDWS
KLPANALSVNSKEGYFVKPSRTNIYNRVLSILGEGITVGPKRFEFLAFSA
SQLRGNSVWMFASNEKVKAEDIREWMGCFRKIRSISKCAARMGQLFSASR
QTLIVRAQDVEQIPDIEVTTDGADYCFSDGIGKISLAFAKQVAQKCGLSH
VPSAFQIRYGGYKGVIAVDRSSFRKLSLRDSMLKFDSNNRMLNVTRWTES
MPCFLNREIICLLSTLGIEDAMFEAMQAVHLSMLGNMLEDRDAALNVLQK
LSGENSKNLLVKMLLQGYAPSSEPYLSMMLRVHHESQLSELKSRCRILVP
KGRILIGCMDEMGILEYGQVYVRVTLTKAELKSRDQSYFRKIDEETSVVI
GKVVVTKNPCLHPGDIRVLDAIYEVHFEEKGYLDCIIFPQKGERPHPNEC
SGGDLDGDQFFVSWDEKIIPSEMDPPMDYAGSRPRLMDHDVTLEEIHKFF
VDYMISDTLGVISTAHLVHADRDPEKARSQKCLELANLHSRAVDFAKTGA
PAEMPYALKPREFPDFLERFEKPTYISESVFGKLYRAVKSSLATAKAHRD
MYGEKLTSLMIYYGAANEEEILTGILKTKEMYLARDNRRYGDMKDRITLS
VKDLHKEAMGWFEKSCEDEQQKKKLASAWYYVTYNPNHRDEKLTFLSFPW
IV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7eu0 Pol IV and RDR2: A two-RNA-polymerase machine that produces double-stranded RNA.
Resolution3.16 Å
Binding residue
(original residue number in PDB)		R417 S477 Q478 S523 R584 K783 D834 D1046 D1049
Binding residue
(residue number reindexed from 1)		R391 S451 Q452 S497 R558 K757 D808 D992 D995
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003727 single-stranded RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005515 protein binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0009751 response to salicylic acid
GO:0010468 regulation of gene expression
GO:0010495 siRNA-mediated long-distance post-transcriptional gene silencing
GO:0030422 siRNA processing
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0050832 defense response to fungus
GO:0140745 siRNA transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7eu0, PDBe:7eu0, PDBj:7eu0
PDBsum7eu0
PubMed34941388
UniProtO82504|RDR2_ARATH RNA-dependent RNA polymerase 2 (Gene Name=RDR2)

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