Structure of PDB 6xr0 Chain M Binding Site BS02

Receptor Information

>6xr0 Chain M (length=683) Species: 9606 (Homo sapiens)

MEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSADHCVQLIAAQ
EADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVT
IDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGG
SCVPGAGETSYSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEG
AGDVAFVKHSTVLENTDGKTLPSWGQALLSQDFELLCRDGSRADVTEWRQ
CHLARVPAHAVVVRADTDGGLIFRLLNEGQRLFSSSFQMFSSEAYGQKDL
LFKDSTSELVPIATQTYEAWLGHEYLHAMKGLLCDPNRLPPYLRWCVLST
PEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQHCMERIQAEQVDAVTLSGE
DIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAVVRRDSSHAFTLDELRGK
RSCHAGFGSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNN
PKNYPSSLCALCVGDEQGRNKCVGNSQERYYGYRGAFRCLVENAGDVAFV
RHTTVFDNTNGHNSEPWAAELRSEDYELLCPNGARAEVSQFAACNLAQIP
PHAVMVRPDTNIFTVYGLLDKAQDLFGDDHNKNGFKMFDSSNYHGQDLLF
KDATVRAVPVGEKTTYRGWLGLDYVAALEGMSS

Ligand information

• Ligand ID: BCT
• InChI: InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1
• InChIKey: BVKZGUZCCUSVTD-UHFFFAOYSA-M
• SMILES:
  OpenEye OEToolkits 1.5.0: C(=O)(O)[O-]
  CACTVS 3.341: OC([O-])=O
  ACDLabs 10.04: [O-]C(=O)O
• Formula: C H O3
• Name: BICARBONATE ION
• PDB chain: 6xr0 Chain M Residue 809

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6xr0 Complex of human Melanotransferrin and SC57.32 Fab fragment reveals novel interdomain arrangement with ferric N-lobe and open C-lobe.
• Resolution: 3.064 Å
• Binding residue (original residue number in PDB): D78 T132 R136 V138 Y210
• Binding residue (residue number reindexed from 1): D58 T112 R116 V118 Y190
• Annotation score: 4

Gene Ontology

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space

External links

• PDB: RCSB:6xr0, PDBe:6xr0, PDBj:6xr0
• PDBsum: 6xr0
• UniProt: P08582|TRFM_HUMAN Melanotransferrin (Gene Name=MELTF)