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Receptor Information

>6uwr Chain M (length=660) Species: 1496 (Clostridioides difficile) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EDLDTDNDNIPDSYERNGYTIKDLIAVKWEDSFAEQGYKKYVSNYLESNT
AGDPYTDYEKASGSFDKAIKTEARDPLVAAYPIVGVGMEKLIISTNEHAS
TDQGKTVSRATTNSKTESNTAGVSVNVGYQNGFTANVTTNYSHTTDNSTA
VQDSNGESWNTGLSINKGESAYINANVRYYNTGTAPMYKVTPTTNLVLDG
DTLSTIKAQENQIGNNLSPGDTYPKKGLSPLALNTMDQFSSRLIPINYDQ
LKKLDAGKQIKLETTQVSGNFGTKNSSGQIVTEGNSWSDYISQIDSISAS
IILDTENESYERRVTAKNLQDPEDKTPELTIGEAIEKAFGATKKDGLLYF
NDIPIDESCVELIFDDNTANKIKDSLKTLSDKKIYNVKLERGMNILIKTP
TYFTNFDDYNNYPSTWSNVNTTNQDGLQGSANKLNGETKIKIPMSELKPY
KRYVFSGYSKDPLTSNSIIVKIKAKEEKTDYLVPEQGYTKFSYEFETTEK
DSSNIEITLIGSGTTYLDNLSITELNSTPEILDEPEVKIPTDQEIMDAHK
IYFADLNFNPSTGNTYINGMYFAPTQTNKEALDYIQKYRVEATLQYSGFK
DIGTKDKEMRNYLGDPNQPKTNYVNLRSYFTGGENIMTYKKLRIYAITPD
DRELLVLSVD

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

6uwr Chain M Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6uwr Structure of the cell-binding component of theClostridium difficilebinary toxin reveals a di-heptamer macromolecular assembly.
Resolution	2.8 Å
Binding residue (original residue number in PDB)	D220 D222 D224 I226 E231
Binding residue (residue number reindexed from 1)	D4 D6 D8 I10 E15
Annotation score	4

Enzyme Commision number

	Biological Process
GO:0051260	protein homooligomerization

	Cellular Component
GO:0005576	extracellular region

PDB	RCSB:6uwr, PDBe:6uwr, PDBj:6uwr
PDBsum	6uwr
PubMed	31896582
UniProt	O32739

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Structure of PDB 6uwr Chain M Binding Site BS02