Structure of PDB 6m44 Chain M Binding Site BS02

Receptor Information
>6m44 Chain M (length=103) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILEL
AGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVL
LPK
Ligand information
>6m44 Chain J (length=355) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgctgacgttttttttttcatgtgccggtctcacacgtgcctggagacta
gtaagcgcttctagtggcggttaaaacgcggtagacagcgcgtacgtgcg
tttaagcggtgctagagctgtctacgaccaattgagcggcctcggcaccg
ggatgcgattttttttttcatactcgagcatgcattttttttttcatgtg
ccggtctcacacgtgcctggagactagtaagcgcttctagtggcggttaa
aacgcggtagacagcgcgtacgtgcgtttaagcggtgctagagctgtcta
cgaccaattgagcggcctcggcaccgggatgcgttttttttttcgtcagc
ggtac
Receptor-Ligand Complex Structure
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PDB6m44 Near-atomic resolution structures of interdigitated nucleosome fibres.
Resolution3.81 Å
Binding residue
(original residue number in PDB)		R29 R42 V43 G44 K75 R77
Binding residue
(residue number reindexed from 1)		R14 R27 V28 G29 K60 R62
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
GO:0061644 protein localization to CENP-A containing chromatin
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0043505 CENP-A containing nucleosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6m44, PDBe:6m44, PDBj:6m44
PDBsum6m44
PubMed32958761
UniProtP04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)

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